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Predicting Higher Risk for Prostate Cancer
Story supplied by LU Press Office
Cells which look abnormal but are not designated precancerous could help predict a future diagnosis of prostate cancer, according to new research.
These abnormal yet non-cancerous cells - known as high-grade prostatic intraepithelial neoplasia (HGPIN) - carry a high predictive value for future diagnosis of prostate cancer.
The research published in the open access journal BMC Urology has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.
Dr Frank Martin a senior lecturer from the University's Lancaster Environment Centre , and Paras Singh, Lancashire Teaching Hospitals NHS Foundation Trust, along with their co-workers, conducted a retrospective analysis of the trust's pathology database, investigating the occurrence of prostate cancer in patients initially diagnosed with HGPIN.
They also calculated the risk of developing prostate cancer based on initial levels of prostate serum antigen (PSA), currently used as a diagnostic marker for prostate cancer.
Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 prostate cancer diagnoses were made. Age at first biopsy, higher baseline PSA and higher change in PSA were all predictive of cancer detection on repeat biopsies.
Dr Martin said: "This pioneering research carried out at Lancaster University in collaboration with Lancashire Teaching Hospitals NHS Trust has the potential to improve important clinical decisions when determining an individual's risk of a future prostate cancer diagnosis in men in the UK."
Wed 27 May 2009
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Latest News
Geography student sets up film company
It is well known that Geography graduates are highly employable and use their degrees in many different ways. One of the more unusual we have heard about recently is Lancaster geographer Greg Tomaszewicz who has set up his own Video Production Company - Lanor Productions.
Story supplied by LU Press Office
Fri 22 February 2013
Eco-innovation businesses invited to attend pioneering project launch
Ambitious North West SMEs keen to drive forward eco-innovative ideas and products are invited to a major event in Manchester on March 4.
Story supplied by LU Press Office
Thu 21 February 2013
First Science and Technology Business Partnerships and Enterprise Annual Report 2011-2012 available to download now
2011-2012 saw the development of a new theme-based strategy for Business Partnerships and Enterprise in Science and Technology. The seven interdisciplinary themes are: Advanced Manufacturing, Energy, Environment, Health and Human Development, Information and Communication Technologies, Quantum Technology and Security. Each theme has dedicated professional staff to work with businesses and source the expertise they need.
Tue 19 February 2013
Lancaster University Coffeemat Challenge won by Science and Technology student Seb
The concept of a new university website, complete with mobile application, to capture the campus social scene at a glance, earned an enterprising student an iPad.
Story supplied by LU Press Office
Tue 19 February 2013