Dr Sue Broughton
Division of Biomedical and Life Sciences
Faculty of Health and Medicine
Tel: +44 1524 593710
Fax: +44 1524 593192
BSc (Hons) Biological Sciences from Leicester University (1987)
PhD from New York University (2002)
My research interests lie in the mechanisms of ageing using the fruit fly, Drosophila melanogaster, as a model organism. I have a particular interest in the role of the insulin/IGF-like signalling pathway in modulating lifespan and age-related functional decline.
S.J. Broughton, T. Ikeya, R. Grandison and L. Partridge. (2009) Removing Wolbachia accentuates mutant insulin signalling in Drosophila. Proc. Roy Soc B. 276(1674):3799-807.
S.J. Broughton and L. Partridge. (2009) Insulin/IGF-like Signalling, the Central Nervous System and Ageing. Biochem J. 418:1-12.
S.J. Broughton, N. Alic, C. Slack, T.M. Bass, T. Ikeya, G. Vinti, A.M. Tommasi, Y. Driege, E. Hafen and L. Partridge. (2008). Targeted Reduction of an Insulin-Like Ligand in Drosophila Triages a Metabolic Phenotype from Lifespan and Reveals Redundancy and Compensation Between Ligands. PLoS ONE 3(11):e3721. [Link]
S.J. Broughton, M.D.W. Piper, T. Ikeya, T.M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D.J. Withers, S.J. Leevers and L. Partridge (2005). Longer lifespan, altered metabolism and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. U.S.A. 102, 3105-3110.
S.J. Broughton, T. Kitamoto and R.J. Greenspan (2004). Excitatory and Inhibitory Switches for Courtship in the Brain of Drosophila melanogaster. Curr. Biol. 14:1-20.
S.J. Broughton, T. Tully and R.J. Greenspan (2003). Conditioning Deficits of CaM-Kinase Transgenic Drosophila melanogaster in a New Excitatory Courtship Assay. J. Neurogenet. 17: 91-102.
S.J. Broughton, N.S. Kane, M. Yoder, R.J. Greenspan, and A. Robichon (1996). Transport of CaM Kinase Along Processes Elicited by Neuronal Contact Evokes an Inhibition of Arborization and Outgrowth in D. melanogaster Cultured Neurons. J. Cell. Biochem. 62:484-494.
S.J. Broughton, N.S. Kane, B. Arthur, M. Yoder, R.J. Greenspan, and A. Robichon (1996). Endogenously Inhibited Protein Kinase C in Transgenic Drosophila Embryonic Neuroblasts Down Regulates the Outgrowth of Type I and II Processes of Cultured Mature Neurons. J. Cell. Biochem. 60:584-599.