Dr Nigel Fullwood
Senior Lecturer
Office B18 / Lab A19
Division of Biomedical and Life Sciences
Faculty of Health and Medicine
Lancaster University
Lancaster
LA1 4YQ
UK
Tel: +44 1524 593474
Fax: +44 1524 593192
E-mail: n.fullwood@lancaster.ac.uk
Research Interests
I am involved in the development of therapies for the preservation and restoration of sight. I have long term collaboration in this area with Kyoto Prefectural Medical University I am currently involved in several projects, listed below.
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The identification and characterisation of stem cells
Research into the causes of corneal dysfunction.
Corneal transplantation.
Development of an artificial cornea.
Development of corneal stem cell therapies.
Development of an in vitro model of the eye.
I am currently funded by the Royal Society, the BBSRC and the EPSRC. Research and graduate student positions are sometimes available in these research areas. I am also on the steering committee of the N8 Centre for Translational Regenerative Medicine which has recently received 2 million phase II funding.
Honours and Prizes
Award of 2004 Daiwa Adrian prize as part of a four person international team working on Corneal Diseases, presented at the Royal Society on 25th November 2004.
Fellow of the Royal Microscopy Society.
Visiting Scientist at Kyoto Prefectural University of Medicine, Japan
Other interests
I teach courses on cell biology, biomedicine and microscopy at the undergraduate and postgraduate level. These include BIOL 112 (Module director), BIOL 211, BIOL 363, BIOL 315 (Module director), BIOL 464 (Module director) Biol 466 (Module director). I am Director of Studies for the MSc Degree in Biomedicine
Degrees Held
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BSc Joint Hons. Genetics and Cell Biology. University of Manchester. 1982
MPhil Physiology. CNAA. 1989
PhD Biophysics. Oxford Research Unit, Open University. 1992
Recent Publications
Takaoka M, Nakamura T, Sugai H, Bentley AJ, Nakajima N, Yokoi N, Fullwood NJ, Hyon SH and Kinoshita S. Novel sutureless keratoplasty with a chemically defined bioadhesive. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2679-85
Fullwood NJ. Microscopy for life scientists. Science. 2008 Sep 12;321(5895):1445.
Nakamura T, Ohtsuka T, Sekiyama E, Cooper LJ, Kokubu H, Fullwood NJ, Barrandon Y, Kageyama R, Kinoshita S. Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells. 2008 May;26(5):1265-74.
Martin FL, Fullwood NJ. Raman vs. Fourier transform spectroscopy in diagnostic medicine. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):E1
Cooper LJ, German M, Koizumi N, Nakamura T, Kinoshita S, Fullwood NJ. A comparison of normal and denuded amniotic membrane for ocular surface reconstruction. Cornea. 2005 Aug;24(6):722-9
Rimmer S, German M J, Maughan J, Sun Y, Fullwood NJ, Ebdon J and MacNeil S. Synthesis and properties of amphiphilic networks 3: preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)) Biomaterials, In Press, 2005
El-Agnaf OM, Paleologou KE, Greer B, Abogrein AM, King JE, Salem SA, Fullwood NJ, Benson FE, Hewitt R, Martin FL, Harriott P, Cookson MR, Allsop D. A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders. FASEB J. 18(11):1315-17. 2004
Moore SA, Huckerby TN, Gibson GL, Fullwood NJ, Turnbull S, Tabner BJ, El-Agnaf OM, Allsop D. Both the d-(+) and l-(-) Enantiomers of Nicotine Inhibit Abeta Aggregation and Cytotoxicity. Biochemistry. 2004 Jan 27;43(3):819-26.
Nakamura T, Yoshitani M, Rigby H, Fullwood NJ, Ito W, Inatomi T, Sotozono C,Nakamura T, Shimizu Y, Kinoshita S. Sterilized, freeze-dried amniotic membrane: a useful substrate for ocular surface reconstruction.Invest Ophthalmol Vis Sci. 2004 Jan;45(1):93-9.
Fullwood NJ. Collagen Fibril Orientation and Corneal Curvature. Structure. 12(2):169-70. 2004
Ishino Y, Sano Y, Nakamura T, Connon CJ, Rigby H, Fullwood NJ, and Kinoshita S. Amniotic Membrane as a Carrier for Cultivated Human Corneal Endothelial Cell Transplantation. Invest Ophthalmol Vis Sci. 45(3):800-6. 2004
Cooper LJ, Fullwood NJ, Koizumi N, Nakamura T, Kinoshita S. An investigation of removed cultivated epithelial transplants in patients after allo-cultivated corneal epithelial transplantation. Cornea. 23(3):235-42. 2004.
Ban Y, Dota A, Cooper LJ, Fullwood NJ, Nakamura T, Tsuzuki M, Mochida C, Kinoshita S. Tight junction-related protein expression and distribution in human corneal epithelium. Experimental Eye Research. 76:663-669. 2003.
Ban Y, Cooper LJ, Fullwood NJ, Nakamura T, Tsuzuki M, Koizumi N, Dota A, Mochida C, Kinoshita S. Comparison of ultrastructure, tight junction-related protein expression and barrier function of human corneal epithelial cells with and without air-lifting. Experimental Eye Research. 76:735-743. 2003.
Nakamura T, Endo K, Cooper LJ, Fullwood NJ, Tanifuji N, Koizumi N, Inatomi T, Sano Y, Kinoshita S. The successful culture and autologous transplantation of rabbit oral mucosal epithelial cells on amniotic membrane. Investigative Ophthalmology and Visual Science. 44:106-116. 2003.
El-Agnaf OMA, Salem SA, Paleologou KE, Cooper LJ, Fullwood NJ, Gibson MJ, Curran MD, Court JA, Mann DMA, Ikeda S, Cookson MR, Hardy> J, Allsop D. Synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma. FASEB J. 17: 1945-1947.2003.
Koizumi N, Cooper LJ, Fullwood NJ, Nakamura T, Inoki K, Tsuzuki M, Kinoshita S.An evaluation of cultivated corneal limbal epithelial cells, using cell-suspension culture. Invest Ophthalmol Vis Sci. 43(7):2114-21. 2002.
Haigh R, Fullwood NJ, Rimmer S. Synthesis and properties of amphiphilic networks 2: a differential scanning calorimetric study of poly(dodecyl methacrylate-stat-2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate) networks and adhesion and spreading of dermal fibroblasts on these materials. Biomaterials. 23(16):3509-16. 2002.
Sugita J, Yokoi N, Fullwood NJ, Quantock AJ, Takada Y, Nakamura Y, Kinoshita S. The detection of bacteria and bacterial biofilms in punctal plug holes. Cornea. May;20(4):362-5. 2001.
Meek, K.M., Fullwood, N.J. Corneal and scleral collagens- from a microscopical perspective. Micron. 1;32(3):261-272. 2001.
Lewis, D., Lawrence, F., Nieduszynski, I., Quantock, A., Bonshek, R. & Fullwood, N.J. The distribution of unsulphated keratan sulphate in Macular Corneal Dystrophy I. Glycobiology. 10: 305-312. 2000.
Koizumi, N., Inatomi, T., Quantock, A.J., Fullwood, N.J., Dota, A., & Kinoshita, S. Amniotic membrane for cultivating limbal corneal epithelial cells for autologous transplantation. Cornea. 19: 65-71 2000.
Koizumi, N., Inatomi, T., Sotozono, C., Fullwood, N.J., Quantock, A.J., & Kinoshita, S. Growth factor mRNA and protein in preserved human amniotic membrane. Current Eye Research. 20: 173-7. 2000.
Kinoshita, S., Nishida, K., Dota, A., Inatomi, T., Koizumi, N., Elliott, A., Lewis, D., Quantock, A. & Fullwood, N.J. Epithelial barrier function and ultrastructure of Gelatinous Corneal Dystrophy. Cornea. 19(4):551-5. 2000.
Lui, Z., Fullwood, N. J., Rimmer, S. Synthesis of allyoxycarbonyloxymethyl-5-flurouracil and copolymerizations with N-vinylpyrrolininone. Journal of Materials Chemistry, 10, 1771-1775. 2000.
Haigh, R., Rimmer, S., Fullwood, N.J. The effect of hydration on non-specific antibody adhesion to polymers. Biomaterials. 21: 735-739. 2000.
Lewis, D., Lawrence, F., Nieduszynski, I., Quantock, A., Bonshek, R. & Fullwood, N.J. The distribution of unsulphated keratan sulphate in Macular Corneal Dystrophy I. Glycobiology. 10: 1-7. 2000.
Koizumi, N., Inatomi, T., Quantock, A.J., Fullwood, N.J., Dota, A. & Kinoshita, S. Amniotic membrane for cultivating limbal corneal epithelial cells for autologous transplantation. Cornea. 2000 Jan;19(1):65-71.
Kinoshita, S., Nishida, K., Dota, A., Inatomi, T., Koizumi, N., Elliott, A., Lewis D., Quantock, A. & Fullwood, N.J. Epithelial barrier function and ultrastructure of Gelatinous Corneal Dystrophy. Cornea. 2000 Jul;19(4):551-5.
Koizumi, N., Fullwood, N.J., Bairaktaris, G., Inatomi, T., Kinoshita, S., Quantock, A.J. Cultivation of corneal epithelial cells on intact and denuded human amniotic membrane. Investigative Ophthalmology and Visual Science. 2000 Aug; 41(9):2506-13. 2000.
Quantock, A.J., Bairaktaris, G, Fullwood, N.J. Ito, M., Suzuki, T. and Kinoshita, S. Endothelial cell surface keratan sulphate after laser photoablation of the cornea. Journal of Refractive Surgery 15, 349-356. 1999.
Rimmer, S., Tattersall, P., Ebdon, J.R., and Fullwood, N.J. New strategies for the synthesis of amphiphilic networks. Reactive and Functional Polymers. 41, 177-184. 1999.
Davies, Y., Lewis, D., Marcyniuk, B., Nieduszynski, I.A., and Fullwood, N.J. Glycosaminoglycan changes in wound-healing human corneal endothelium. Experimental Eye Research. 68, 303-311. 1999.