Dr Karen Wright

Peel Trust Lecturer in Biomedicine

Publications

Alhamoruni A, Lee AC, Wright KL, Larvin M and O'Sullivan SE. (2010) Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability. J Pharmacol Exp Ther 335(1): 92-102.

Karen L. Wright, Duncan A.F. Robertson, Mary Pat Moyer and Stephen G. Ward. (2008). Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer. Int J Cancer. 122, 1920-1921.

Karen L. Wright, Marnie Duncan and Keith A. Sharkey. (2008) Cannabinoid (CB)-2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br. J. Pharmacol. 153(2), 263-70.

Karen Coopman, Laura D. Smith, Karen L. Wright and Stephen G. Ward. (2007) Temporal variation in CB(2)R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis. Int Immunopharmacol. 7(3), 360-71.

Orr Ofek, Meliha Karsak, Nathalie Leclerc, Meirav Fogel, Baruch Frenkel, Karen Wright, Joseph Tam, Malka Attar-Namdar, Vardit Kram, Esther Shohami, Raphael Mechoulam, Andreas Zimmer, and Itai Bab (2006) Peripheral cannabinoid receptor, CB2, regulates bone mass. PNAS, 103(3), 696-701.

Kouroumalis A, Aptel H, Nibbs RJ, Wright KL, Kolios G, Ward SG. (2005) The chemokines CXCL9, CXCL10 and CXCL11 differentially stimulate G i-independent signalling and actin responses in human intestinal myofibroblasts. J. Immunol. 175 (8), 5403-5411.

Wright KL, Rooney N, Feeney M, Tate J, Robertson DAF, Welham MJ and Ward SG. (2005) Differential expression of functional cannabinoid receptors in human colonic epithelium: evidence that cannabinoids promote wound healing. Gastroenterology 129(2), 437-453.

Patel K, Wright KL, Whittaker P, Chakravarty P, Watson M and Ward SG. (2005) Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR agonists: evidence for disparate functional effects which are independent of NF- B and PPAR . Cell Sig. 17(9), 1098-110.

Wright KL, Weaver SA, Patel K, Coopman K, Feeney M, Kolios G, Robertson DAF and Ward SG. (2004) Differential regulation of prostaglandin E biosynthesis by interferon- ?in epithelial cells. Br. J. Pharmacol. 141(7), 1091-1097.

Curnock AP, Sotsios Y, Wright KL and Ward SG. (2003) Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases. J Immunol. 170(8), 4021-30.

Freeburn RW, Wright KL, Burgess SJ, Astoul E, Cantrell DA and Ward SG. (2002) Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J Immunol. 169(10), 5441-50.

Weaver SA, Pia Russo M, Wright KL, Kolios G, Jobin C, Robertson DAF and Ward SG. (2001) Regulatory role of phosphatidylinositol 3-kinase on TNF -induced cyclooxygenase-2 expression in colonic epithelial cells. Gastroenterology, 120(5), 1117-1127.

Wright KL and Ward SG. (2000) Interactions between phosphatidylinositol 3-kinase and nitric oxide: explaining the paradox. Minireview Mol. Cell. Biol. Res. Commun., 4(3), 137-143.

Kolios G, Wright KL, Linehan JD, Robertson DAF and Westick J. (2000) Interleukin-13 inhibits nitric oxide production in human colonic mucosa. Hepato-Gastroenterology 47, 714-717.

Wright KL, Kolios G, Westwick J and Ward SG. (1999) Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation: evidence for an IL-13-driven PI3-kinase-dependent survival mechanism. J. Biol. Chem. 276, 17193-17201.

Kolios, G., Wright, K.L., Jordan, N.J., Leithead, J.B., Robertson, D.A.F. and Westwick, J. (1999) C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: differential effect of T lymphocyte-derived cytokines. Eur. J. Immunol. 29, 530-536.

Wright, K., Ward, S.G., Kolios, G. and Westwick, J. (1997) Activation of phosphatidylinositol 3-kinase by interleukin-13 - An inhibitory signal for inducible nitric-oxide synthase expression in the epithelial, cell line HT-29. J. Biol. Chem., 272, 12626-12633.

Kolios G, Wright KL, Jordan NJ, Leithead JB, Murphy CT, Robertson DAF and Westwick J. (1997) Regulation of inflammatory mediator production in human colonic epithelial cells. Hell. J. Gastroenterol. 10, 135-147.