This module is an introduction to cellular biochemistry focusing on the core pathways of intermediary metabolism which are central to cellular function. Specifically, it focuses on two related and key areas of biochemistry. The first is enzymology; how do proteins function as biological catalysts and how are chemical reactions controlled within a cell? Students will investigate how the many chemical reactions which participate in metabolism are accurately regulated and organised.

The second is cellular metabolism; particularly, how do cells obtain energy from their surroundings to maintain their complex order?

The module will cover several seminal and Nobel Prize winning research topics including a detailed look at the key reactions of the citric acid cycle and the coupling of electron transport, proton pumping and ATP synthesis. The concepts and areas of biochemistry covered will be further illustrated by reference to the pathological state and human diseases which result from specific malfunctions in biochemical pathways and reactions.

This module explores the interactions that take place both within and between cells and which allow them to perform their function in the whole organism. Students will consider five key topics within cell biology:

• The methods used to study cells and the dynamic nature of the cytoskeleton
• The mechanisms and physiological significance of transport across membranes
• The mechanisms involved in cells receiving and acting upon information from outside of the cell
• The mechanisms of development of whole organisms, examining how individual cells become committed to a particular function as development occurs
• The regulation of the cell cycle, growth, and development. We will illustrate these topics using examples drawn from a range of biological system.

The aim of this module is to provide students with the skills they need to begin their future careers. The module will enhance career awareness, develop oral communications skills and develop CV and cover letter writing. Workshops include sessions on LinkedIn, information skills, assessment centres, interview techniques and entrepreneurship.

This module takes a molecular approach to understanding heredity and gene function in organisms ranging from bacteria to man. It begins by reviewing genome diversity and how genomes are replicated accurately, comparing and contrasting replication processes in bacteria and man. The module discusses in detail molecular mechanisms, particularly those that ensure information encoded in the genome is transcribed and translated appropriately to produce cellular proteins.

Students will focus on the importance of maintaining genome stability and damaging effects of mutations in the genome on human health. Examples are drawn from a range of inherited genetic diseases such as phenylketonuria and sickle cell anaemia, paying particular focus to how mutations in key genes are driving cancer development.

Teaching is delivered by a series of lectures supported by varied practical work, workshops, guided reading and online resources. Laboratory practicals include investigating how exposure of bacteria to ultraviolet light induces mutations – providing a model for understanding how skin cancer may develop as a consequence of excessive sun exposure.

This course examines the relationship between microbe and host; with particular focus on bacterial and viral pathogens. The diversity of structure, function and metabolism of bacteria, in relation to their role as a cause of disease, is explored and practical skills in bacteriology are introduced. Morphology and reproductive strategies of viruses are examined and methods for controlling viral infections by vaccination or anti-viral therapies are described. The course introduces principles of clinical microbiology by focusing on epidemiology, diagnosis, treatment of infection and host immune defences. The theme is one of "emergence" illustrating how some new infections have come to be a problem in health care and the importance of protective commensal microbes. The laboratory classes focus on diagnostic processes and illustrate the contribution which the microbiology laboratory can make to clinical decision making and epidemiology. This course also deals with the way in which pathogens (mainly bacteria) survive, and sometimes grow, in the environment and the implications this has for health in the community. The course is given in collaboration with health service consultants and workers from the University Hospitals of Morecambe Bay NHS Trust.

The aim of this module is to use real-world examples to provide you with an in-depth understanding of critical concepts in the science of pharmacology, including pharmacodynamics and pharmacokinetics. You will gain insight into pharmacodynamic concepts such as Emax, EC50, Kd and receptor occupancy and how these relate to both how drugs are administered and their effects on the body.

In addition to looking at how drugs affect the body, we'll also discuss how the body affects drugs, with an in-depth exploration of the pharmacokinetic parameters of absorption, distribution metabolism and excretion (ADME). Adverse effects of drugs and how these can be mitigated will be considered. We'll look at how drug formulation and route of delivery can alter ADME characteristics, enabling a drug's effects to be fine-tuned to achieve the required clinical outcome. You'll also explore examples of other factors that affect pharmacokinetics, including age, sex, ethnicity, pregnancy and medication status. We'll conclude by considering the influence of individual and population genetics on drug responses and what this means for both drug discovery and personalised medicine.

Lectures are supported by practical classes and workshops to enable you to develop your understanding of pharmacological concepts and see how theory is put into practice.

This module will provide you with an understanding of the steps involved in taking a lead compound through to market. You will gain insight into the challenges associated with developing and assessing the efficacy and safety of new drugs, including the testing strategies and legal requirements involved

We will explore the use of preclinical models for testing of pharmacokinetic and pharmacodynamic parameters and how this can aid in determining factors such as drug formulation and dosing schedule. We will then move on to discussing the role of clinical trials in determining drug safety and efficacy, looking in-depth at trial design and also considering the importance of post-approval surveillance. The module will also provide contextual information on how preclinical and clinical trials fit into the international medicines regulatory process and its requirements.

The aim of this module is to take you through the methods used in the discovery stages of the drug development process. We'll begin by discussing the techniques used for target identification and validation before moving on to hit identification and lead discovery. You will learn about different approaches for finding new drugs: from high throughput screening of compound libraries to focused screens and the role of virtual screens and structure-based drug design. We'll conclude by discussing the experimental techniques that are used for in vitro testing of lead compounds for activity and toxicity.

Lectures will be complemented by workshops and practicals where you will gain hands-on experience of some of the techniques covered in the module.

This module will provide an in-depth exploration of novel pharmacological approaches that are revolutionising the treatment of many conditions. You will first be introduced to new concepts in the design and use of small molecules to treat disease. For example, we'll look at how PROTACs and molecular glues can be used to degrade target proteins rather than inhibit them.

We'll also discuss recently emerging therapeutic avenues such as biologics, nanotechnology, cell and gene therapy, immunological therapies and other medicine modalities. You'll gain an understanding of how these approaches work and the benefits they offer in treating and preventing disease.

The research project gives students first-hand experience of research and also the opportunity to be immersed in, and learn about, an area of work which is of current interest. Students plan, conduct and report on an open-ended investigation, often related to research interests of a member of staff. Projects cover a very wide variety of topics and may be carried out in a variety of ways. They involve a significant amount of original work and analysis to be carried out by students so that they gain experience in a range of skills, including experimental design and the testing of hypotheses. The results of the research are reported in an 8,000 word dissertation and an oral presentation.

In this module students are given an overview of the cellular and molecular processes that underpin the development of cancer. This will enable students to discuss the various factors that can affect cancer susceptibility. Students will look at the approaches taken to treat cancer, including some of the new generation of molecularly-targeted cancer therapies.

The mammalian nervous system acts as the central regulator of physiology and behaviour, and its function can be modified by a diverse range of exogenous small molecules. Humans have utilised these small molecules for hunting, recreation, in biomedical research and for therapeutic purposes.

In this module you will develop a detailed understanding of how a diverse range of chemical agents impact on the function of the nervous system, along with the molecular targets and neurotransmitter systems involved. This will include consideration of small molecules used by humans recreationally, medically and those used in the context of treating disorders of nervous system. The therapeutic role of drugs in the treatment of mood, neurodevelopmental and psychiatric disorders will be considered. In addition, you will develop insight into recent advances in the drug development and validation process for novel drugs that act upon the nervous system, along with the range of models and experimental approaches utilised in this process.

Curriculum outline

For 50 years, thanks to evolutionary theory, we’ve known why we are fated to age and die, but our understanding of the mechanisms has been a lengthy evolution in itself. Only relatively recently, with the use of modern molecular biology tools, do we begin to understand the mechanistic basis of the ageing process, from early notions about rates of living to current ideas about modular yet interacting mechanisms including autophagy, protein synthesis, nutrient sensing, insulin-like signalling and disease resistance. Even now we do not clearly know what makes us age. Ageing is perhaps the most multidisciplinary area of study and is certainly one of the last great mysteries in biology.

This module introduces the area and the methodologies with which ageing is studied. Teaching is through lectures, workshops, practical work, individual and group-based coursework and private study.

This module explores some of the key roles played by ion channels and calcium ions in the communication that takes place within and between cells. The module is split into two linked themes. Firstly, an introduction to the diversity of ion channel families and their biological functions including the many different cellular processes throughout the life history of cells that are regulated by calcium ions as signals. Secondly, an investigation of the importance of ion channels and calcium signalling in animals, and human physiology in particular, using examples of diseases that are caused when ion channels malfunction (e.g. myotonia, malignant hyperthermia, sudden heart arrest caused by long QT syndrome.) or calcium signalling is disrupted (e.g. Alzheimer’s disease, polycystic kidney disease, pancreatitis). Students also gain hands-on experience of the techniques used to study ion channels and calcium signalling in cells.

Every day our body does something remarkable, but we are completely unaware of it most of the time: our immune system is constantly protecting us from pathogens in our environment as well as threats from within. This highly evolved, interdependent collection of organs, cells and chemical messengers is continually scanning our tissues for any unwanted intruders or abnormal cells. When we get ill, with a cold for example, full mobilisation of our immune system sends armies of cells and molecules to fight the problem in what can sometimes literally be a fight to the death. Fortunately for us, our immune system wins the battle almost every time!

In this module we examine the various components of the immune system – the organs, cells, and messengers, and how they function in health and illness. We look at particular threats such as allergies, infectious diseases and cancer, providing students with a good understanding of how this vital component of our bodies keeps us well.

Research and practice in biomedicine continues to evolve more rapidly than at any other time in history, raising fascinating but complex moral and ethical challenges for those studying and working in the field. Understanding ethics in biomedicine and the relationship between science and society has become an essential element in biomedical degree training.

This module builds on the Biomedicine and Society module, aiming to help students develop a deeper understanding of key ethical principles used in biomedicine and some major cultural, social and political influences that define research agendas and fuel ethical debates in the public perception of biomedicine.

The module takes on a seminar format structured around three core themes:

• The development of ethical principles in biomedicine
• Ethical practice and current debates in animal and human research including clinical trials
• Ethical challenges such as those emerging in genetics and regenerative medicine and how these are debated in the media.

In this module students will work together as a team to propose a solution to a problem of biological relevance, for example antibiotic resistance, invasive species or healthy ageing. The solution may be a patentable, commercial product or a policy proposal. Weekly workshop sessions will be held for the whole class which will include presentations from external speakers on topics such as intellectual property, project management and negotiating skills. Each team will choose a leader who will be responsible for organising regular meetings in which ideas are developed, tasks assigned and information gathered. The team will produce a report in the form of a patent application or policy document which will form part of the module assessment. The remainder of the assessment will be based on an oral presentation. Peer-assessment will be used to adjust tutors' marks according to individual contribution to the project.

This module aims to provide an understanding of the organisation of the human genome, how disease genes are mapped and how mutations are identified leading to the development of diagnostic tests. The impacts of massively parallel next generation DNA sequencing, microarrays and SNP genotyping on gene discovery and disease diagnosis are examined. The application of modern genetic techniques to identifying susceptibility genes for complex, multifactorial traits will also be studied. A range of diseases will be examined in detail both in lectures and in case study workshop sessions. The final lecture looks at gene therapy and considers the future for treatment of genetic disorders. The practical session aims to give students an opportunity to study their own DNA in a forensics scenario, using techniques that are widely applicable in modern molecular genetics.

Students will be introduced to the importance of molecular, metabolic and cellular interactions within parasitic protists, and between a range of parasitic protists and their hosts.

The course will provide students with an understanding of how the life cycle strategies used by protists enable them to gain access to, and survive within, the host as well as the impact that protist parasites have on human health. Practicals will provide an opportunity for students to apply immunological skills to investigate the host-parasite interaction.

Microbiology for the biomedical scientist comprises screening samples to identify and assess microbiological pathogens that cause disease and, enable front line medical staff to choose the correct therapy for successful eradication of the infection. Increasing numbers of these infections are community acquired and many are contracted from, or in, the environment. The environment therefore plays an increasing role in the life cycle and ecology of many pathogens. This in turn, is having an increasing impact on human health and national health services. The increase is a combination of changing environmental conditions (such as land use changes, global warming) and an ever evolving microbial community, most of which do not harm but a few can cause mild to fatal diseases when the opportunity arises. Also cycling in the environment are obligate pathogens which will cause infections if contracted. Furthermore, there are new diseases emerging (e.g. Ebola) and others thought to have been controlled are now re-emerging such as cholera. Using specific microbial pathogens as examples, this module examines the factors and interactions that allow microbial infections to be transmitted from the environment to humans and how their life cycle plays an important role in their emergence, persistence, transmission and infection. It also examines antibiotic resistance: how it has emerged, the different types of resistance, its management and the complications that it imposes on the treatment of these diseases.

Assessment:

1. Exam: 2 hour paper with two questions in sections A and B. Students are required to answer one question from each.

2. Coursework is an extended essay of 2000 words based on the lectures and field trip. The title will be announced in the first lecture.

Understanding how life works depends to a great extent on understanding how proteins work. Thanks to the Human Genome Project, we now have a catalogue of all the proteins that are encoded in the human genome. This might be thought of as life’s toolbox. The next questions are: how do those tools work; how do they interact with each other; and how have they evolved over the billions of years of evolutionary time that have led to us? This module introduces modern techniques for the study of protein structure, function and evolution.

Lectures cover: structural-functional relationships in proteins; methods for detecting the action of Darwinian selection in protein evolution; methods for reconstructing the evolutionary events that have led to present-day proteins; and, the new lab techniques that are allowing us to study protein function on a large scale. In the practical sessions, students will gain hands-on experience of molecular phylogenetics – the main tool for studying evolution at the molecular level – as it is applied to proteins. Assessment is by an exam and a coursework essay on a protein of your choice, giving students a chance to apply their new knowledge of protein biochemistry to any of their own areas of interest in biology.